Nandrolone decanoate is an anabolic steroid indicated for the management of the anemia of renal insufficiency by increasing hemoglobin and red cell mass.
Nandrolone decanoate, also known as nandrolone caprinate, is an alkylated anabolic steroid indicated in the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of senile and postmenopausal osteoporosis. The process for creating esters of nandrolone was patented in Spain in 1959 and in 1960, it was described as having a long duration of action and strong anabolic effect compared to nandrolone and other esters.
Nandrolone Decanoate can be attached to just about any ester, and that flexibility makes it very commonly used. It is often attached to the Cypionate ester. It is a go to for athletes during the off season when they are interested in bulking up and getting stronger. Athletes also enjoy the healing benefits of Nandrolone Decanoate so they can recovery from workouts and injuries faster. The controversy over steroids has reduce the use of it for medical purposes but the use of it for athletes remains very high.
Nandrolone decanoate is an alkylated anabolic steroid indicated in the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of senile and postmenopausal osteoporosis.
It has a long duration of action as it is given every 3-4 weeks, and a wide therapeutic window as acute overdoses are rare. Patients should be counselled regarding the risks of giving this drug to patients with cardiac, renal, or hepatic diseases.
Nandrolone Decanoate is a 19-Nortestosterone anabolic androgenic steroid. This refers to the structure changes to the testosterone hormone as it lacks the carbon atom which is normally in the 19th position. It is this change that makes the benefits from the steroid Nandrolone Decanoate possible!
The anabolic rating of Nandrolone Decanoate is just a bit higher than testosterone. However, it has a far less androgenic rate. When you compare them, testosterone has an androgenic rating of 100 and it is only 37 for Nandrolone Decanoate. This is because the steroid reduces DHN rather than DHT.
Nandrolone decanoate is hydrolyzed to nandrolone, possibly by PDE7B. Nandrolone is brought into cells by receptor mediated endocytosis, where it interacts with the androgen receptor. After binding to the androgen receptor, a conformational change occurs, the androgen receptor enters the nucleus, dimerizes, and can then bind to segments of DNA to regulate transcription.
Androgens can also regulate transcription through activation of ERK, Akt, and MAPK; or binding to and competitively inhibiting transcription factors.
It is the only anabolic steroid that offers benefits for bone minerals and collagen. As a result, Nandrolone Decanoate promotes healthy joints, reduces pain and stiffness, and helps the ligaments and tendons to heal faster after workouts. All of this adds up to Nandrolone Decanoate having plenty of benefits to offer to the user.
Metabolism: Nandrolone decanoate is hydrolyzed to nandrolone, possibly by PDE7B. Data regarding the percent protein binding of nandrolone decanoate is not readily available. After nandrolone decanoate is hydrolyzed to nandrolone, it is bound to sex hormone binding globulin.
Absorption: A 50 mg intramuscular dose of nandrolone decanoate reaches a mean Cmax 2.14 ng/mL, with a mean Tmax of 30 hours, and a mean AUC of 400 h*ng/mL. A 100 mg intramuscular dose of nandrolone decanoate reaches a mean Cmax 4.26 ng/mL, with a mean Tmax of 30 hours, and a mean AUC of 862 h*ng/mL. A 150 mg intramuscular dose of nandrolone decanoate reaches a mean Cmax 5.16 ng/mL, with a mean Tmax of 72 hours, and a mean AUC of 1261 h*ng/mL.
Route of elimination: Nandrolone decanoate is eliminated as urinary metabolites, however data regarding elimination in the feces are not readily available.7 Data in cattle shows that nandrolone is 30% eliminated in the feces.
Half life: Nandrolone decanoate has an absorption half life of 6 days and an elimination half life of 4.3 hours. Alternate studies have shown that nandrolone decanoate has a terminal half life of 7.1, 11.7, and 11.8 hours for doses of 50, 100, and 150 mg respectively.
All medicines may cause side effects, but many people have no, or minor, side effects. Some medical conditions may interact with Nandrolone decanoate.
Tell your doctor or pharmacist if you have any medical conditions.
Data regarding acute overdose of nandrolone decanoate are not readily available. However, patients experiencing a chronic overdose of anabolic steroids may experience adverse effects including suppression of testosterone and spermatogenesis, shrinking of testicles, decreased libido, and erectile dysfunction in men; and suppressed estrogen, progesterone, and ovulation, amenorrhea, and clitoromegaly in women. Patients may also experience neuropsychiatric, cardiovascular, and hepatic adverse effects.8 Alkylated anabolic steroids such as nandrolone decanoate are more likely to cause hepatic adverse effects.8 Treat patients with symptomatic and supportive measures.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.
